Solubility of the poorly soluble drug like deferasirox was enhanced by using physical mixing, kneading and solvent evaporation method. Drug and carriers like PVP K30 in different ratios like 1: 1, 1: 1.5 and 1: 2 were used for formulating solid dispersions. Sachet dosage form of deferasirox along with solubility enhancement was successfully formulated by employing solvent evaporation method followed by direct mixing and filling method. Carrier likes PVP K-30 is more enhanced the solubility of deferasirox compared to other carriers polyethylene glycol 6000 (PEG 6000), poloxamer 188 and HPMC 3 cps. Solubility of deferasirox is more enhanced by using solid dispersion prepared by solvent evaporation method compared to physical mixing, kneading method. Batch F7 having Drug-carrier (PVP K30) ratio of 1:1.5 and 3 % colloidal silicone dioxide showed excellent results of various parameters likes physicotechnical parameters solubility study, drug content, drug release compared to other batches. Evaluation parameters like angle of repose, assay and dissolution evaluated for all the formulations. Percentage weight variation was found to be within the approved range (Indian Pharmacopoeial Standards) for all the formulations. The in-vitro release studies showed >85% of drug release in batches with solid dispersion 1:1.5 to 1:2 at 45 minutes. Overall, in the formulations prepared, F7 which contain drug: polymer ratio 1:1.5 and colloidal silicon dioxide 3% found to be best formulation, F7 was optimized batch.
Loading....